Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

• Main Authors: Gluckman, Peter D., Zhang, C., Masuda, S., Kambadur, R., McFarlane, Craig, Lokireddy, Sudarsanareddy, Ge, Xiaojia, Sharma, Mridula
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/97641; http://hdl.handle.net/10220/13216
• Institution: Nanyang Technological University

Aims/hypothesis Although myostatin-null (Mstn −/−) mice fail to accumulate fat in adipose tissue when fed a high-fat diet (HFD), little is known about the molecular mechanism(s) behind this phenomenon. We therefore sought to identify the signalling pathways through which myostatin regulates accumul...