Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis

• Main Authors: Guo Y., Tan L.-J., Lei S.-F., Yang T.-L., Chen X.-D., Zhang F., Chen Y., Pan F., Yan H., Liu X., Tian Q., Zhang Z.-X., Zhou Q., Qiu C., Dong S.-S., Xu X.-H., Guo Y.-F., Zhu X.-Z., Liu S.-L., Wang X.-L., Li X., Luo Y., Zhang L.-S., Li M., Wang J.-T., Wen T., Drees B., Hamilton J., Papasian C.J., Recker R.R., Song X.-P., Cheng J., Deng H.-W.
• Other Authors: DEPT OF CHEMISTRY
• Format: Article
• Published: 2019
• Subjects: acetaldehyde; aldehyde dehydrogenase; ALDH7A1 protein, human; adult; aged; aging; aldh7a1 gene; article; bone density; case control study; Caucasian; cell proliferation; Chinese; chromosome 5; controlled study; female; follow up; gene; gene identification; gene replication; genetic susceptibility; genome analysis; groups by age; human; major clinical study; male; ossification; osteoblast; osteoporosis; pathogenesis; risk factor; single nucleotide polymorphism; Asian; genetic association; genetic predisposition; genetics; middle aged; pathophysiology; Aged; Aldehyde Dehydrogenase; Asian Continental Ancestry Group; Bone Density; Case-Control Studies; European Continental Ancestry Group; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Middle Aged; Osteoporosis; Polymorphism, Single Nucleotide
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161668
• Institution: National University of Singapore

10.1371/journal.pgen.1000806