An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia

• Main Authors: Her Z., Yong K.S.M., Paramasivam K., Tan W.W.S., Chan X.Y., Tan S.Y., Liu M., Fan Y., Linn Y.C., Hui K.M., Surana U., Chen Q.
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: regorafenib; sorafenib; stem cell factor receptor; acute myeloid leukemia; acute myeloid leukemia cell line; animal cell; animal experiment; animal model; animal tissue; Article; blood analysis; bone marrow; CD34 selection; cell activity; cell differentiation; cell infiltration; cell subpopulation; disease course; drug screening; drug sensitivity; engraftment; human; human cell; mouse; nonhuman; phenotype; preclinical study; primary cell line; spleen; splenomegaly; therapy effect; transplantation; tumor xenograft; animal; disease model; genetics; nonobese diabetic mouse; pathology; procedures; SCID mouse; xenograft; Animals; Disease Models, Animal; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Transplantation, Heterologous
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173769
• Institution: National University of Singapore

10.1186/s13045-017-0532-x