Small molecule targeting malaria Merozoite surface protein-1 (MSP-1) prevents host invasion of divergent Plasmodial species

• Main Authors: Chandramohanadas R., Russell B., Liew K., Yau Y.H., Chong A., Liu M., Gunalan K., Raman R., Renia L., Nosten F., Shochat S.G., Dao M., Sasisekharan R., Suresh S., Preiser P.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Oxford University Press 2020
• Subjects: 2 butyl 5 chloro 3 (4 nitro benzyl) 3h imidazole 4 carbaldehyde; ligand; merozoite surface protein 1; unclassified drug; antimalarial agent; Article; binding affinity; carboxy terminal sequence; computer model; controlled study; in vitro study; merozoite; molecular docking; nonhuman; parasite phenomena and functions; Plasmodium falciparum; Plasmodium vivax; protein analysis; protein binding; protein localization; protein protein interaction; sequence alignment; species invasion; surface plasmon resonance; antagonists and inhibitors; drug effects; endocytosis; human; isolation and purification; Antimalarials; Endocytosis; Humans; Merozoite Surface Protein 1
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175315
• Institution: National University of Singapore

10.1093/infdis/jiu296