Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice

Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice

10.18632/oncotarget.4956

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Bibliographic Details
Main Authors:	Goh, A.M, Xue, Y, Leushacke, M, Li, L, Wong, J.S, Chiam, P.C, Binte Rahmat, S.A, Mann, M.B, Mann, K.M, Barker, N, Lozano, G, Terzian, T, Lane, D.P
Other Authors:	BIOCHEMISTRY
Format:	Article
Published:	Impact Journals LLC 2020
Subjects:	Lgr5 protein protein MDM2 protein p53 stem cell factor unclassified drug enzyme inhibitor Mdm2 protein, mouse animal cell animal tissue Article cell cycle cell differentiation cell proliferation controlled study crypt cell DNA damage down regulation gene dosage gene expression genotype immunoreactivity in vitro study ionizing radiation mouse nonhuman protein degradation protein depletion protein expression protein induction protein metabolism radiation dose 129 mouse age animal antagonists and inhibitors C57BL mouse diagnostic imaging drug effects gene expression regulation genetics knockout mouse metabolism mutation phenotype radiography small intestine time factor tissue culture technique Age Factors Animals Cell Cycle Cell Differentiation Cell Proliferation DNA Damage Enzyme Inhibitors Gene Expression Regulation Genotype Intestine, Small Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mutation Phenotype Proto-Oncogene Proteins c-mdm2 Radiography Time Factors Tissue Culture Techniques Tumor Suppressor Protein p53
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/177759
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Institution:	National University of Singapore

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