Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice

• Main Authors: Goh, A.M, Xue, Y, Leushacke, M, Li, L, Wong, J.S, Chiam, P.C, Binte Rahmat, S.A, Mann, M.B, Mann, K.M, Barker, N, Lozano, G, Terzian, T, Lane, D.P
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: Lgr5 protein; protein MDM2; protein p53; stem cell factor; unclassified drug; enzyme inhibitor; Mdm2 protein, mouse; animal cell; animal tissue; Article; cell cycle; cell differentiation; cell proliferation; controlled study; crypt cell; DNA damage; down regulation; gene dosage; gene expression; genotype; immunoreactivity; in vitro study; ionizing radiation; mouse; nonhuman; protein degradation; protein depletion; protein expression; protein induction; protein metabolism; radiation dose; 129 mouse; age; animal; antagonists and inhibitors; C57BL mouse; diagnostic imaging; drug effects; gene expression regulation; genetics; knockout mouse; metabolism; mutation; phenotype; radiography; small intestine; time factor; tissue culture technique; Age Factors; Animals; Cell Cycle; Cell Differentiation; Cell Proliferation; DNA Damage; Enzyme Inhibitors; Gene Expression Regulation; Genotype; Intestine, Small; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phenotype; Proto-Oncogene Proteins c-mdm2; Radiography; Time Factors; Tissue Culture Techniques; Tumor Suppressor Protein p53
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/177759
• Institution: National University of Singapore

10.18632/oncotarget.4956