Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination

• Main Authors: Acosta, M.I, Urbach, S, Doye, A, Ng, Y.-W, Boudeau, J, Mettouchi, A, Debant, A, Manser, E, Visvikis, O, Lemichez, E
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: bacterial toxin; cytotoxic necrotizing factor 1; Escherichia coli protein; HACE1 protein, human; p21 activated kinase; Rac1 protein; RAC1 protein, human; serine; ubiquitin protein ligase; vasculotropin A; cell line; chemistry; human; metabolism; phosphorylation; protein multimerization; proteomics; ubiquitination; umbilical vein endothelial cell; Bacterial Toxins; Cell Line; Escherichia coli Proteins; Human Umbilical Vein Endothelial Cells; Humans; p21-Activated Kinases; Phosphorylation; Protein Multimerization; Proteomics; rac1 GTP-Binding Protein; Serine; Ubiquitin-Protein Ligases; Ubiquitination; Vascular Endothelial Growth Factor A
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178469
• Institution: National University of Singapore

10.1038/s41598-018-19471-2