TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling

10.18632/oncotarget.5362

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Main Authors:	Ke, X, Zhao, Y, Lu, X, Wang, Z, Liu, Y, Ren, M, Lu, G, Zhang, D, Sun, Z, Xu, Z, Song, J.H, Cheng, Y, Meltzer, S.J, He, S
Other Authors:	ELECTRICAL AND COMPUTER ENGINEERING
Format:	Article
Published:	2020
Subjects:	cyclin D1 cyclin dependent kinase 2 Notch receptor protein Bax protein bcl 2 protein p21 thymoquinone antineoplastic agent apoptosis regulatory protein benzoquinone derivative cell cycle protein NOTCH1 protein, human Notch1 receptor animal experiment animal model animal tissue apoptosis Article cancer inhibition cell proliferation cell viability controlled study down regulation G1 phase cell cycle checkpoint hepatocellular carcinoma cell line human human cell in vitro study in vivo study liver cell carcinoma male mouse nonhuman protein blood level protein expression signal transduction tumor growth upregulation animal Bagg albino mouse Carcinoma, Hepatocellular cell cycle checkpoint dose response drug effects drug screening gene expression regulation genetic transfection genetics Hep-G2 cell line Liver Neoplasms metabolism nude mouse pathology time factor tumor volume Animals Antineoplastic Agents, Phytogenic Apoptosis Apoptosis Regulatory Proteins Benzoquinones Cell Cycle Checkpoints Cell Cycle Proteins Cell Proliferation Dose-Response Relationship, Drug Down-Regulation Gene Expression Regulation, Neoplastic Hep G2 Cells Humans Male Mice, Inbred BALB C Mice, Nude Receptor, Notch1 Signal Transduction Time Factors Transfection Tumor Burden Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180934
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1809342024-11-09T20:24:00Z TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling Ke, X Zhao, Y Lu, X Wang, Z Liu, Y Ren, M Lu, G Zhang, D Sun, Z Xu, Z Song, J.H Cheng, Y Meltzer, S.J He, S ELECTRICAL AND COMPUTER ENGINEERING cyclin D1 cyclin dependent kinase 2 Notch receptor protein Bax protein bcl 2 protein p21 thymoquinone antineoplastic agent apoptosis regulatory protein benzoquinone derivative cell cycle protein NOTCH1 protein, human Notch1 receptor thymoquinone animal experiment animal model animal tissue apoptosis Article cancer inhibition cell proliferation cell viability controlled study down regulation G1 phase cell cycle checkpoint hepatocellular carcinoma cell line human human cell in vitro study in vivo study liver cell carcinoma male mouse nonhuman protein blood level protein expression signal transduction tumor growth upregulation animal Bagg albino mouse Carcinoma, Hepatocellular cell cycle checkpoint dose response drug effects drug screening gene expression regulation genetic transfection genetics Hep-G2 cell line Liver Neoplasms metabolism nude mouse pathology signal transduction time factor tumor volume Animals Antineoplastic Agents, Phytogenic Apoptosis Apoptosis Regulatory Proteins Benzoquinones Carcinoma, Hepatocellular Cell Cycle Checkpoints Cell Cycle Proteins Cell Proliferation Dose-Response Relationship, Drug Down-Regulation Gene Expression Regulation, Neoplastic Hep G2 Cells Humans Liver Neoplasms Male Mice, Inbred BALB C Mice, Nude Receptor, Notch1 Signal Transduction Time Factors Transfection Tumor Burden Xenograft Model Antitumor Assays 10.18632/oncotarget.5362 Oncotarget 6 32 32610-32621 2020-10-27T05:46:04Z 2020-10-27T05:46:04Z 2015 Article Ke, X, Zhao, Y, Lu, X, Wang, Z, Liu, Y, Ren, M, Lu, G, Zhang, D, Sun, Z, Xu, Z, Song, J.H, Cheng, Y, Meltzer, S.J, He, S (2015). TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling. Oncotarget 6 (32) : 32610-32621. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.5362 19492553 https://scholarbank.nus.edu.sg/handle/10635/180934 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	cyclin D1 cyclin dependent kinase 2 Notch receptor protein Bax protein bcl 2 protein p21 thymoquinone antineoplastic agent apoptosis regulatory protein benzoquinone derivative cell cycle protein NOTCH1 protein, human Notch1 receptor thymoquinone animal experiment animal model animal tissue apoptosis Article cancer inhibition cell proliferation cell viability controlled study down regulation G1 phase cell cycle checkpoint hepatocellular carcinoma cell line human human cell in vitro study in vivo study liver cell carcinoma male mouse nonhuman protein blood level protein expression signal transduction tumor growth upregulation animal Bagg albino mouse Carcinoma, Hepatocellular cell cycle checkpoint dose response drug effects drug screening gene expression regulation genetic transfection genetics Hep-G2 cell line Liver Neoplasms metabolism nude mouse pathology signal transduction time factor tumor volume Animals Antineoplastic Agents, Phytogenic Apoptosis Apoptosis Regulatory Proteins Benzoquinones Carcinoma, Hepatocellular Cell Cycle Checkpoints Cell Cycle Proteins Cell Proliferation Dose-Response Relationship, Drug Down-Regulation Gene Expression Regulation, Neoplastic Hep G2 Cells Humans Liver Neoplasms Male Mice, Inbred BALB C Mice, Nude Receptor, Notch1 Signal Transduction Time Factors Transfection Tumor Burden Xenograft Model Antitumor Assays
spellingShingle	cyclin D1 cyclin dependent kinase 2 Notch receptor protein Bax protein bcl 2 protein p21 thymoquinone antineoplastic agent apoptosis regulatory protein benzoquinone derivative cell cycle protein NOTCH1 protein, human Notch1 receptor thymoquinone animal experiment animal model animal tissue apoptosis Article cancer inhibition cell proliferation cell viability controlled study down regulation G1 phase cell cycle checkpoint hepatocellular carcinoma cell line human human cell in vitro study in vivo study liver cell carcinoma male mouse nonhuman protein blood level protein expression signal transduction tumor growth upregulation animal Bagg albino mouse Carcinoma, Hepatocellular cell cycle checkpoint dose response drug effects drug screening gene expression regulation genetic transfection genetics Hep-G2 cell line Liver Neoplasms metabolism nude mouse pathology signal transduction time factor tumor volume Animals Antineoplastic Agents, Phytogenic Apoptosis Apoptosis Regulatory Proteins Benzoquinones Carcinoma, Hepatocellular Cell Cycle Checkpoints Cell Cycle Proteins Cell Proliferation Dose-Response Relationship, Drug Down-Regulation Gene Expression Regulation, Neoplastic Hep G2 Cells Humans Liver Neoplasms Male Mice, Inbred BALB C Mice, Nude Receptor, Notch1 Signal Transduction Time Factors Transfection Tumor Burden Xenograft Model Antitumor Assays Ke, X Zhao, Y Lu, X Wang, Z Liu, Y Ren, M Lu, G Zhang, D Sun, Z Xu, Z Song, J.H Cheng, Y Meltzer, S.J He, S TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling
description	10.18632/oncotarget.5362
author2	ELECTRICAL AND COMPUTER ENGINEERING
author_facet	ELECTRICAL AND COMPUTER ENGINEERING Ke, X Zhao, Y Lu, X Wang, Z Liu, Y Ren, M Lu, G Zhang, D Sun, Z Xu, Z Song, J.H Cheng, Y Meltzer, S.J He, S
format	Article
author	Ke, X Zhao, Y Lu, X Wang, Z Liu, Y Ren, M Lu, G Zhang, D Sun, Z Xu, Z Song, J.H Cheng, Y Meltzer, S.J He, S
author_sort	Ke, X
title	TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling
title_short	TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling
title_full	TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling
title_fullStr	TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling
title_full_unstemmed	TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling
title_sort	tq inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of notch signaling
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/180934
_version_	1821211930923106304

TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling

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