TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling

TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling

10.18632/oncotarget.5362

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Bibliographic Details
Main Authors:	Ke, X, Zhao, Y, Lu, X, Wang, Z, Liu, Y, Ren, M, Lu, G, Zhang, D, Sun, Z, Xu, Z, Song, J.H, Cheng, Y, Meltzer, S.J, He, S
Other Authors:	ELECTRICAL AND COMPUTER ENGINEERING
Format:	Article
Published:	2020
Subjects:	cyclin D1 cyclin dependent kinase 2 Notch receptor protein Bax protein bcl 2 protein p21 thymoquinone antineoplastic agent apoptosis regulatory protein benzoquinone derivative cell cycle protein NOTCH1 protein, human Notch1 receptor animal experiment animal model animal tissue apoptosis Article cancer inhibition cell proliferation cell viability controlled study down regulation G1 phase cell cycle checkpoint hepatocellular carcinoma cell line human human cell in vitro study in vivo study liver cell carcinoma male mouse nonhuman protein blood level protein expression signal transduction tumor growth upregulation animal Bagg albino mouse Carcinoma, Hepatocellular cell cycle checkpoint dose response drug effects drug screening gene expression regulation genetic transfection genetics Hep-G2 cell line Liver Neoplasms metabolism nude mouse pathology time factor tumor volume Animals Antineoplastic Agents, Phytogenic Apoptosis Apoptosis Regulatory Proteins Benzoquinones Cell Cycle Checkpoints Cell Cycle Proteins Cell Proliferation Dose-Response Relationship, Drug Down-Regulation Gene Expression Regulation, Neoplastic Hep G2 Cells Humans Male Mice, Inbred BALB C Mice, Nude Receptor, Notch1 Signal Transduction Time Factors Transfection Tumor Burden Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180934
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Institution:	National University of Singapore

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