TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling

• المؤلفون الرئيسيون: Ke, X, Zhao, Y, Lu, X, Wang, Z, Liu, Y, Ren, M, Lu, G, Zhang, D, Sun, Z, Xu, Z, Song, J.H, Cheng, Y, Meltzer, S.J, He, S
• مؤلفون آخرون: ELECTRICAL AND COMPUTER ENGINEERING
• التنسيق: مقال
• منشور في: 2020
• الموضوعات: cyclin D1; cyclin dependent kinase 2; Notch receptor; protein Bax; protein bcl 2; protein p21; thymoquinone; antineoplastic agent; apoptosis regulatory protein; benzoquinone derivative; cell cycle protein; NOTCH1 protein, human; Notch1 receptor; animal experiment; animal model; animal tissue; apoptosis; Article; cancer inhibition; cell proliferation; cell viability; controlled study; down regulation; G1 phase cell cycle checkpoint; hepatocellular carcinoma cell line; human; human cell; in vitro study; in vivo study; liver cell carcinoma; male; mouse; nonhuman; protein blood level; protein expression; signal transduction; tumor growth; upregulation; animal; Bagg albino mouse; Carcinoma, Hepatocellular; cell cycle checkpoint; dose response; drug effects; drug screening; gene expression regulation; genetic transfection; genetics; Hep-G2 cell line; Liver Neoplasms; metabolism; nude mouse; pathology; time factor; tumor volume; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Benzoquinones; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Receptor, Notch1; Signal Transduction; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays
• الوصول للمادة أونلاين: https://scholarbank.nus.edu.sg/handle/10635/180934
• المؤسسة: National University of Singapore

10.18632/oncotarget.5362