The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

• Main Authors: Yuen, J.S.P, Cockman, M.E, Sullivan, M, Protheroe, A, Turner, G.D.H, Roberts, I.S, Pugh, C.W, Werner, H, Macaulay, V.M
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: HuR protein; somatomedin C receptor; transcription factor Sp1; von Hippel Lindau protein; animal cell; article; cell survival; clear cell carcinoma; controlled study; Drosophila; genetic transcription; human; human cell; hypoxia; kidney biopsy; kidney carcinoma; nonhuman; priority journal; prognosis; protein binding; protein expression; protein motif; protein stability; receptor upregulation; reverse transcription polymerase chain reaction; Carcinoma, Renal Cell; Humans; Kidney; Kidney Neoplasms; Receptor, IGF Type 1; RNA, Messenger; Sp1 Transcription Factor; Transcription, Genetic; Tumor Cells, Cultured; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181031
• Institution: National University of Singapore

10.1038/sj.onc.1210474