Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia

• Main Authors: Sanda, T, Li, X, Gutierrez, A, Ahn, Y, Neuberg, D.S, O'Neil, J, Strack, P.R, Winter, C.G, Winter, S.S, Larson, R.S, Von Boehmer, H, Look, A.T
• Other Authors: MEDICINE
• Format: Article
• Published: American Society of Hematology 2020
• Subjects: alvespimycin; chaperone; gamma secretase inhibitor; heat shock protein 90; heat shock protein 90 inhibitor; histone deacetylase; immunoglobulin enhancer binding protein; Myc protein; Notch1 receptor; phosphatidylinositol 3 kinase; proteasome inhibitor; protein kinase B; tumor suppressor protein; unclassified drug; enzyme inhibitor; NOTCH1 protein, human; Notch1 protein, mouse; secretase; acute lymphoblastic leukemia; algorithm; analysis; animal cell; animal model; article; cancer growth; cancer inhibition; cell growth; cell survival; comparative study; controlled study; down regulation; drug sensitivity; female; gene; gene expression; human; human cell; in vitro study; leukemia cell; leukemogenesis; mouse; nonhuman; nucleotide sequence; pathogenesis; prediction; priority journal; signal transduction; T lymphocyte; animal; cell cycle; cell proliferation; cell transformation; drug antagonism; experimental leukemia; gene expression profiling; genetics; metabolism; oncogene myc; species difference; tumor cell line; Amyloid Precursor Protein Secretases; Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Down-Regulation; Enzyme Inhibitors; Gene Expression Profiling; Genes, myc; Humans; Leukemia, Experimental; Mice; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Receptor, Notch1; Signal Transduction; Species Specificity
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183915
• Institution: National University of Singapore

10.1182/blood-2009-07-235143