Long-term safety and efficacy of ravulizumab in patients with paroxysmal nocturnal hemoglobinuria: 2-year results from two pivotal phase 3 studies

• Main Authors: Kulasekararaj, AG, Griffin, M, Langemeijer, S, Usuki, K, Kulagin, A, Ogawa, M, Yu, J, Mujeebuddin, A, Nishimura, JI, Lee, JW, Peffault de Latour, R, 301/302 Study Group, Latypova, A, Barcellini, W, Barraco, F, Beam, D, Bettelheim, P, Borisenkova, E, Brodsky, A, Carnley, B, Cermak, J, Chen, TY, Chew, LP, Chew, TK, Choi, CW, Choi, Y, Chung, JS, De Guibert, S, Devos, T, Dunaev, Y, Dwilewicz-Trojaczek, J, Edahiro, Y, Elykomov, I, Engelberger, MI, Pomponi, F, Fuereder, W, Fujii, N, Fujiwara, S, Galieni, P, Gaya Valls, A, Girault, S, Gomez Almaguer, D, Gonzalez Fernandez, FA, Gritsaev, S, Gunduz, E, Hantaweepant, C, Harada, H, Höglund, M, Huang, WH, Husin, A, Ikezoe, T, Ishiyama, K, Ito, Y, Jang, JH, Jo, DY, Kang, KW, Kennedy, J, Kim, HJ, Kim, JA, Kim, JS, Kimura, F, Kobune, M, Kosugi, H, Kulasekararaj, A, Lai, KM, Larratt, L, Lee, GW, Lee, JH, Lin, CC, Lukina, E, Martynova, E, Matsumura, I, Meike, G, Menosi Gualandro, SF, Minaeva, N, Mori, Y, Morita, K, Morselli Ramalho, FM, Mun, YC, Muus, P, Myasnikov, A, Naito, K, Ninomiya, H, Nogami, A, Notaro, R, Ojeda Gutierrez, E, Okada, M, Okamoto, S, Olkhovik, T, Pane, F, Paquette, R, Park, JS, Peffault de la Tour, R, Piatek, C, Piekarska, A, Pontes Reis, ML, Pospelova, T, Ptushkin, V, Roeth, A
• Other Authors: MEDICINE
• Format: Article
• Published: Wiley 2023
• Subjects: breakthrough hemolysis; complement inhibitor; lactate dehydrogenase; paroxysmal nocturnal hemoglobinuria; ravulizumab; Antibodies, Monoclonal, Humanized; Complement C5; Complement Inactivating Agents; Hemoglobinuria, Paroxysmal; Hemolysis; Humans
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/245612
• Institution: National University of Singapore

10.1111/ejh.13783