Parboiled Germinated Brown Rice Decreases Inflammatory Cytokines Levels in Various Regions of Brain in Rats Induced by Carbon Tetrachloride
Chiang Mai University (CMU) Journal of Natural Sciences is dedicated to the publication of original research in Sciences & Technology and the Health Sciences. Submissions are welcomed from CMU, as well as other Thai and foreign institutions. All submissions must be original research not previous...
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2020
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th-cmuir.6653943832-686622020-05-20T04:41:50Z Parboiled Germinated Brown Rice Decreases Inflammatory Cytokines Levels in Various Regions of Brain in Rats Induced by Carbon Tetrachloride Kansuda Wunjuntuk Somsri Chareonkiatkul Aikkarach Kettawan Brain inflammation Parboiled germinated brown rice Carbon tetrachloride Khao Dawk Mali 105 KDML 105 Chiang Mai University (CMU) Journal of Natural Sciences is dedicated to the publication of original research in Sciences & Technology and the Health Sciences. Submissions are welcomed from CMU, as well as other Thai and foreign institutions. All submissions must be original research not previously published or simultaneously submitted for publication. Manuscripts are peer reviewed using the double -blinded review system by at least 2 reviewers before acceptance. The CMU Journal of Natural Sciences is published four times a year, in January, April, July and October. Parboiled germinated brown rice (PGBR) from the Khao Dawk Mali 105 (KDML 105) Thai rice strain is well-known for its nutrients and bioactive compounds. This research was conducted to determine the protective effect of PGBR on carbon tetrachloride (CCl4)-induced brain inflammation. Thirty-five male Sprague-Dawley rats were randomly divided into five groups: (I) control group (basal diet); (II) CCl4 group (basal diet); (III) white rice + CCl4 group; (IV) brown rice + CCl4 group, and (V) PGBR + CCl4 group. PGBR, brown rice and white rice diets were produced by replacing cornstarch in basal diet with cooked PGBR, brown rice, and white rice, respectively. Twice weekly, each rat was orally administrated with 1 mL/kg of CCl4 in olive oil (1:1, v/v). After eight weeks, all rats were subjected to carbon dioxide euthanasia. The cerebral cortex, hippocampus and cerebellum were dissected and homogenised to evaluate the levels of tumour necrosis factor α (TNF-α), interleukin 1β (IL-1β), and interleukin 6 (IL-6). It was observed that the administration of CCl4 induced the elevation of the TNF-α and IL-1β levels in all brain tissues, as well as the blood ammonia and serum liver functions also rose. However, there was a significant reduction in the levels of TNF-α and IL-1β in the cerebral cortex, hippocampus and cerebellum in the PGBR + CCl4 group compared to the CCl4 group (P<0.05), whereas the blood ammonia and serum liver functions were also decreased. These findings suggest that regular consumption of PGBR may prevent CCl4-induced brain inflammation. 2020-05-20T04:41:50Z 2020-05-20T04:41:50Z 2020 Chiang Mai University (CMU) Journal of Natural Sciences 19,2 (Apr-Jun 2020), p.265-279 2465-4337 http://cmuj.cmu.ac.th/uploads/journal_list_index/37627667.pdf http://cmuir.cmu.ac.th/jspui/handle/6653943832/68662 Eng Chiang Mai University |
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Brain inflammation Parboiled germinated brown rice Carbon tetrachloride Khao Dawk Mali 105 KDML 105 |
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Brain inflammation Parboiled germinated brown rice Carbon tetrachloride Khao Dawk Mali 105 KDML 105 Kansuda Wunjuntuk Somsri Chareonkiatkul Aikkarach Kettawan Parboiled Germinated Brown Rice Decreases Inflammatory Cytokines Levels in Various Regions of Brain in Rats Induced by Carbon Tetrachloride |
| description |
Chiang Mai University (CMU) Journal of Natural Sciences is dedicated to the publication of original research in Sciences & Technology and the Health Sciences. Submissions are welcomed from CMU, as well as other Thai and foreign institutions. All submissions must be original research not previously published or simultaneously submitted for publication. Manuscripts are peer reviewed using the double -blinded review system by at least 2 reviewers before acceptance. The CMU Journal of Natural Sciences is published four times a year, in January, April, July and October. |
| author |
Kansuda Wunjuntuk Somsri Chareonkiatkul Aikkarach Kettawan |
| author_facet |
Kansuda Wunjuntuk Somsri Chareonkiatkul Aikkarach Kettawan |
| author_sort |
Kansuda Wunjuntuk |
| title |
Parboiled Germinated Brown Rice Decreases Inflammatory Cytokines Levels in Various Regions of Brain in Rats Induced by Carbon Tetrachloride |
| title_short |
Parboiled Germinated Brown Rice Decreases Inflammatory Cytokines Levels in Various Regions of Brain in Rats Induced by Carbon Tetrachloride |
| title_full |
Parboiled Germinated Brown Rice Decreases Inflammatory Cytokines Levels in Various Regions of Brain in Rats Induced by Carbon Tetrachloride |
| title_fullStr |
Parboiled Germinated Brown Rice Decreases Inflammatory Cytokines Levels in Various Regions of Brain in Rats Induced by Carbon Tetrachloride |
| title_full_unstemmed |
Parboiled Germinated Brown Rice Decreases Inflammatory Cytokines Levels in Various Regions of Brain in Rats Induced by Carbon Tetrachloride |
| title_sort |
parboiled germinated brown rice decreases inflammatory cytokines levels in various regions of brain in rats induced by carbon tetrachloride |
| publisher |
Chiang Mai University |
| publishDate |
2020 |
| url |
http://cmuj.cmu.ac.th/uploads/journal_list_index/37627667.pdf http://cmuir.cmu.ac.th/jspui/handle/6653943832/68662 |
| _version_ |
1681752672657473536 |