Humanized monoclonal antibodies derived from chimpanzee fabs protect against Japanese encephalitis virus in vitro and in vivo

Humanized monoclonal antibodies derived from chimpanzee fabs protect against Japanese encephalitis virus in vitro and in vivo

Japanese encephalitis virus (JEV)-specific Fab antibodies were recovered by repertoire cloning from chimpanzees initially immunized with inactivated JE-VAX and then boosted with attenuated JEV SA14-14-2. From a panel of 11 Fabs recovered by different panning strategies, three highly potent neutraliz...

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Main Authors:	Ana P. Goncalvez, Cheng Hsin Chien, Kamolchanok Tubthong, Inna Gorshkova, Carrie Roll, Olivia Donau, Peter Schuck, Sutee Yoksan, Sy Dar Wang, Robert H. Purcell, Ching Juh Lai
其他作者:	National Institute of Allergy and Infectious Diseases
格式:	Article
出版:	2018
主題:	Agricultural and Biological Sciences Immunology and Microbiology
在線閱讀:	https://repository.li.mahidol.ac.th/handle/123456789/18725
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

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