Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several d...
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th-mahidol.313062018-10-19T11:39:20Z Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia Olivo Miotto Jacob Almagro-Garcia Magnus Manske Bronwyn MacInnis Susana Campino Kirk A. Rockett Chanaki Amaratunga Pharath Lim Seila Suon Sokunthea Sreng Jennifer M. Anderson Socheat Duong Chea Nguon Char Meng Chuor David Saunders Youry Se Chantap Lon Mark M. Fukuda Lucas Amenga-Etego Abraham V.O. Hodgson Victor Asoala Mallika Imwong Shannon Takala-Harrison François Nosten Xin Zhuan Su Pascal Ringwald Frédéric Ariey Christiane Dolecek Tran Tinh Hien Maciej F. Boni Cao Quang Thai Alfred Amambua-Ngwa David J. Conway Abdoulaye A. Djimdé Ogobara K. Doumbo Issaka Zongo Jean Bosco Ouedraogo Daniel Alcock Eleanor Drury Sarah Auburn Oliver Koch Mandy Sanders Christina Hubbart Gareth Maslen Valentin Ruano-Rubio Dushyanth Jyothi Alistair Miles John O'Brien Chris Gamble Samuel O. Oyola Julian C. Rayner Chris I. Newbold Matthew Berriman Chris C.A. Spencer Gilean McVean Nicholas P. Day Nicholas J. White Delia Bethell Arjen M. Dondorp Christopher V. Plowe Rick M. Fairhurst Dominic P. Kwiatkowski University of Oxford Mahidol University Wellcome Trust Sanger Institute Wellcome Trust Centre for Human Genetics National Institute of Allergy and Infectious Diseases National Center for Parasitology, Entomology and Malaria Control Armed Forces Research Institute of Medical Sciences, Thailand USAMC-AFRIMS Armed Forces Health Surveillance Center Navrongo Health Research Center University of Maryland School of Medicine Shoklo Malaria Research Unit Organisation Mondiale de la Sante Institut Pasteur, Paris Oxford University Clinical Research Unit Medical Research Council Laboratories Gambia London School of Hygiene & Tropical Medicine University of Sciences Institut de Recherche en Sciences de la Santé Menzies School of Health Research Weatherall Institute of Molecular Medicine Biochemistry, Genetics and Molecular Biology We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalog of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in transporter proteins and DNA mismatch repair proteins. These data provide a population-level genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist in its elimination. © 2013 Nature America, Inc. All rights reserved. 2018-10-19T04:39:20Z 2018-10-19T04:39:20Z 2013-06-01 Article Nature Genetics. Vol.45, No.6 (2013), 648-655 10.1038/ng.2624 15461718 10614036 2-s2.0-84878715473 https://repository.li.mahidol.ac.th/handle/123456789/31306 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878715473&origin=inward |
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Biochemistry, Genetics and Molecular Biology Olivo Miotto Jacob Almagro-Garcia Magnus Manske Bronwyn MacInnis Susana Campino Kirk A. Rockett Chanaki Amaratunga Pharath Lim Seila Suon Sokunthea Sreng Jennifer M. Anderson Socheat Duong Chea Nguon Char Meng Chuor David Saunders Youry Se Chantap Lon Mark M. Fukuda Lucas Amenga-Etego Abraham V.O. Hodgson Victor Asoala Mallika Imwong Shannon Takala-Harrison François Nosten Xin Zhuan Su Pascal Ringwald Frédéric Ariey Christiane Dolecek Tran Tinh Hien Maciej F. Boni Cao Quang Thai Alfred Amambua-Ngwa David J. Conway Abdoulaye A. Djimdé Ogobara K. Doumbo Issaka Zongo Jean Bosco Ouedraogo Daniel Alcock Eleanor Drury Sarah Auburn Oliver Koch Mandy Sanders Christina Hubbart Gareth Maslen Valentin Ruano-Rubio Dushyanth Jyothi Alistair Miles John O'Brien Chris Gamble Samuel O. Oyola Julian C. Rayner Chris I. Newbold Matthew Berriman Chris C.A. Spencer Gilean McVean Nicholas P. Day Nicholas J. White Delia Bethell Arjen M. Dondorp Christopher V. Plowe Rick M. Fairhurst Dominic P. Kwiatkowski Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia |
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We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalog of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in transporter proteins and DNA mismatch repair proteins. These data provide a population-level genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist in its elimination. © 2013 Nature America, Inc. All rights reserved. |
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University of Oxford |
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University of Oxford Olivo Miotto Jacob Almagro-Garcia Magnus Manske Bronwyn MacInnis Susana Campino Kirk A. Rockett Chanaki Amaratunga Pharath Lim Seila Suon Sokunthea Sreng Jennifer M. Anderson Socheat Duong Chea Nguon Char Meng Chuor David Saunders Youry Se Chantap Lon Mark M. Fukuda Lucas Amenga-Etego Abraham V.O. Hodgson Victor Asoala Mallika Imwong Shannon Takala-Harrison François Nosten Xin Zhuan Su Pascal Ringwald Frédéric Ariey Christiane Dolecek Tran Tinh Hien Maciej F. Boni Cao Quang Thai Alfred Amambua-Ngwa David J. Conway Abdoulaye A. Djimdé Ogobara K. Doumbo Issaka Zongo Jean Bosco Ouedraogo Daniel Alcock Eleanor Drury Sarah Auburn Oliver Koch Mandy Sanders Christina Hubbart Gareth Maslen Valentin Ruano-Rubio Dushyanth Jyothi Alistair Miles John O'Brien Chris Gamble Samuel O. Oyola Julian C. Rayner Chris I. Newbold Matthew Berriman Chris C.A. Spencer Gilean McVean Nicholas P. Day Nicholas J. White Delia Bethell Arjen M. Dondorp Christopher V. Plowe Rick M. Fairhurst Dominic P. Kwiatkowski |
format |
Article |
author |
Olivo Miotto Jacob Almagro-Garcia Magnus Manske Bronwyn MacInnis Susana Campino Kirk A. Rockett Chanaki Amaratunga Pharath Lim Seila Suon Sokunthea Sreng Jennifer M. Anderson Socheat Duong Chea Nguon Char Meng Chuor David Saunders Youry Se Chantap Lon Mark M. Fukuda Lucas Amenga-Etego Abraham V.O. Hodgson Victor Asoala Mallika Imwong Shannon Takala-Harrison François Nosten Xin Zhuan Su Pascal Ringwald Frédéric Ariey Christiane Dolecek Tran Tinh Hien Maciej F. Boni Cao Quang Thai Alfred Amambua-Ngwa David J. Conway Abdoulaye A. Djimdé Ogobara K. Doumbo Issaka Zongo Jean Bosco Ouedraogo Daniel Alcock Eleanor Drury Sarah Auburn Oliver Koch Mandy Sanders Christina Hubbart Gareth Maslen Valentin Ruano-Rubio Dushyanth Jyothi Alistair Miles John O'Brien Chris Gamble Samuel O. Oyola Julian C. Rayner Chris I. Newbold Matthew Berriman Chris C.A. Spencer Gilean McVean Nicholas P. Day Nicholas J. White Delia Bethell Arjen M. Dondorp Christopher V. Plowe Rick M. Fairhurst Dominic P. Kwiatkowski |
author_sort |
Olivo Miotto |
title |
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia |
title_short |
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia |
title_full |
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia |
title_fullStr |
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia |
title_full_unstemmed |
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia |
title_sort |
multiple populations of artemisinin-resistant plasmodium falciparum in cambodia |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/31306 |
_version_ |
1763487684577198080 |