Development of a Novel Anti-CD19 CAR Containing a Fully Human scFv and Three Costimulatory Domains

Development of a Novel Anti-CD19 CAR Containing a Fully Human scFv and Three Costimulatory Domains

Second-generation anti-CD19-chimeric antigen receptor T cells (anti-CD19-CAR2 T cells) are effective for treating B-cell malignancies; however, anti-CD19-CAR2 T cells can induce human anti-mouse immune responses because anti-CD19 single-chain variable fragment (scFv) in the CAR molecules is derived...

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Bibliographic Details
Main Authors:	Yupanun Wutti-in, Jatuporn Sujjitjoon, Nunghathai Sawasdee, Aussara Panya, Katesara Kongkla, Pornpimon Yuti, Petlada Yongpitakwattana, Chutamas Thepmalee, Mutita Junking, Thaweesak Chieochansin, Naravat Poungvarin, Montarop Yamabhai, Pa Thai Yenchitsomanus
Other Authors:	Siriraj Hospital
Format:	Article
Published:	2022
Subjects:	Biochemistry, Genetics and Molecular Biology Medicine
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/73465
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	Mahidol University

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