Stereoselective β-C-glycosylation by a palladium-catalyzed decarboxylative allylation : formal synthesis of aspergillide A

• Main Authors: Xiang, Shaohua, Cai, Shuting, Liu, Xue-Wei, Zeng, Jing, Ma, Jimei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds
• Online Access: https://hdl.handle.net/10356/102577; http://hdl.handle.net/10220/19122
• Institution: Nanyang Technological University

Mild and sweet: The title reaction proceeds under mild conditions with high regio- and diastereoselectivity (see scheme, PG=protecting group, DiPPF=1,1′-bis(diisopropylphosphino)ferrocene). This reaction is suitable for a wide range of glycal-derived γ-ketone esters and affords C-glycosides with exc...