Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays

• Main Authors: Brown, Christopher J., Ferrer, Fernando J., Yuen, Tsz Ying, Quah, Soo Tng, Chan, Boon Hong, Teo, Hsiang Ling, Nordlund, Pär, Lane, David P., Tan, Ban Xiong, Jansson, Anna Elisabet
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/103179; http://hdl.handle.net/10220/38721
• Institution: Nanyang Technological University

Previous publications on stapled peptide inhibitors against Mdm2/Mdm4-p53 interactions have established that this new class of drugs have the potential to be easily optimised to attain high binding affinity and specificity, but the mechanisms controlling their cellular uptake and target engagement r...