Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket

Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket

The DNA binding domain (DBD) of the tumor suppressor p53 is the site of several oncogenic mutations. A subset of these mutations lowers the unfolding temperature of the DBD. Unfolding leads to the exposure of a hydrophobic β-strand and nucleates aggregation which results in pathologies through loss...

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書目詳細資料
Main Authors:	Siau, Jia Wei, Kannan, Srinivasaraghavan, Ouaray, Zohra, Kwoh, Chee Keong, Ghadessy, Farid, Pradhan, Mohan Rajan, Nguyen, Minh N., Lane, David P., Verma, Chandra Shekhar
其他作者:	School of Computer Science and Engineering
格式:	Article
語言:	English
出版:	2019
主題:	DNA Binding Domain P53 DRNTU::Science::Biological sciences
在線閱讀:	https://hdl.handle.net/10356/105824 http://hdl.handle.net/10220/48748
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!
機構:	Nanyang Technological University
語言:	English

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