The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity
The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. However, pinpointing cellular determinants of the best...
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| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/105922 http://hdl.handle.net/10220/48858 |
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| Institution: | Nanyang Technological University |
| Language: | English |