Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in P seudomonas aeruginosa

• Main Authors: Yam, Joey Kuok Hoong, Liu, Yang, Chua, Song Lin, Givskov, Michael, Nielsen, Thomas E., Tolker-Nielsen, Tim, Cao, Bin, Yang, Liang, Chen, Yicai, Yuan, Mingjun, Mohanty, Anee
• Other Authors: School of Civil and Environmental Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology
• Online Access: https://hdl.handle.net/10356/107430; http://hdl.handle.net/10220/25532; http://dx.doi.org/10.1111/1758-2229.12278
• Institution: Nanyang Technological University

The nucleotide signalling molecule bis-(3'-5’)-cyclic dimeric guanosine monophosphate (c-di-GMP) plays an essential role in regulating microbial virulence and biofilm formation. C-di-GMP is synthesized by diguanylate cyclase (DGC) enzymes and degraded by phosphodiesterase (PDE) enzymes. One int...