Synthesis of substituted γ- and δ-lactams through mannich-type reactions of solid-supported N -acyliminium ions

• Main Authors: Komnatnyy, Vitaly V., Taveras, Kennedy M., Nandurkar, Nitin S., Le Quement, Sebastian T., Givskov, Michael, Nielsen, Thomas Eiland
• Other Authors: Singapore Centre for Environmental Life Sciences Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/107485; http://hdl.handle.net/10220/25576; http://dx.doi.org/10.1002/ejoc.201500054
• Institution: Nanyang Technological University

We report the results of our recent investigations into the reactivity of cyclic solid-supported N-acyliminium ions. An intermolecular Mannich-type transformation of these intermediates was used to generate libraries of substituted lactams. Masked aldehyde building blocks were readily prepared and c...