Genome-wide RNAi screen identify melanoma-associated antigen Mageb3 involved in X chromosome inactivation

• Main Authors: Li, Wei, Hong, Ru, Lai, Lan-Tian, Dong, Qiman, Ni, Peiling, Chelliah, Rosi, Huq, Mehnaz, Siti Nadirah Ismail, Chandola, Udita, Ang, Zhiwei, Lin, Bingqing, Chen, Xin, Chen, Lingyi, Zhang, Li-Feng
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Xist; Mageb3
• Online Access: https://hdl.handle.net/10356/139663
• Institution: Nanyang Technological University

Xist (inactivated X chromosome specific transcript) is a prototype long noncoding RNA in charge of epigenetic silencing of one X chromosome in each female cell in mammals. In a genetic screen, we identify Mageb3 and its homologs Mageb1 and Mageb2 as genes functionally required for Xist-mediated gene...