Access to planar chiral ferrocenes via N-heterocyclic carbene-catalyzed enantioselective desymmetrization reactions

• Main Authors: Lv, Xiaokang, Xu, Jun, Sun, Cuiyun, Su, Fen, Cai, Yuanlin, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Planar Chiral Molecule Synthesis; N-Heterocyclic Carbene
• Online Access: https://hdl.handle.net/10356/161338
• Institution: Nanyang Technological University

Ferrocene-derived dicarbaldehydes bearing pro-chiral planes are desymmetrized under the catalysis of chiral N-heterocyclic carbene organic catalysts. The reaction features selective activation and reaction of one of the aldehyde moieties of the ferrocene derivative while leaving the other aldehyde u...