Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug

Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug

We report two structures of the human voltage-gated potassium channel (Kv) Kv1.3 in immune cells alone (apo-Kv1.3) and bound to an immunomodulatory drug called dalazatide (dalazatide-Kv1.3). Both the apo-Kv1.3 and dalazatide-Kv1.3 structures are in an activated state based on their depolarized volta...

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書目詳細資料
Main Authors:	Tyagi, Anu, Ahmed, Tofayel, Jian, Shi, Bajaj, Saumya, Ong, Seow Theng, Goay, Stephanie Shee Min, Zhao, Yue, Vorobyov, Igor, Tian, Changlin, Chandy, K. George, Bhushan, Shashi
其他作者:	School of Biological Sciences
格式:	Article
語言:	English
出版:	2022
主題:	Science::Biological sciences Ion Channels Potassium Channels
在線閱讀:	https://hdl.handle.net/10356/162571
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

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