Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth

• Main Authors: Ku, Zhiqiang, Xie, Xuping, Lin, Jianqing, Gao, Peng, Wu, Bin, El Sahili, Abbas, Su, Hang, Liu, Yang, Ye, Xiaohua, Tan, Eddie Yongjun, Li, Xin, Fan, Xuejun, Goh, Boon Chong, Xiong, Wei, Boyd, Hannah, Muruato, Antonio E., Deng, Hui, Xia, Hongjie, Zou, Jing, Kalveram, Birte K., Menachery, Vineet D., Zhang, Ningyan, Lescar, Julien, Shi, Pei-Yong, An, Zhiqiang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Bispecific Antibody; Immunoglobulin G
• Online Access: https://hdl.handle.net/10356/168647
• Institution: Nanyang Technological University

One major limitation of neutralizing antibody-based COVID-19 therapy is the requirement of costly cocktails to reduce emergence of antibody resistance. Here we engineer two bispecific antibodies (bsAbs) using distinct designs and compared them with parental antibodies and their cocktail. Single mole...