First x-ray crystal structure characterization, computational studies, and improved synthetic route to the bioactive 5-arylimino-1,3,4-thiadiazole derivatives

• Main Authors: Moussa, Ziad, Paz, Alejandro Perez, Judeh, Zaher M. A., Alzamly, Ahmed, Saadeh, Haythem A., Asghar, Basim H., Alsaedi, Sara, Masoud, Bayan, Almeqbaali, Salama, Estwani, Saeda, Aljaberi, Amna, Al-Rooqi, Munirah M., Ahmed, Saleh A.
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Isothiocyanate; Hydrazonoyl Chloride
• Online Access: https://hdl.handle.net/10356/169571
• Institution: Nanyang Technological University

N-arylcyanothioformamides are useful coupling components for building key chemical intermediates and biologically active molecules in an expedited and efficient manner. Similarly, substituted (Z)-2-oxo-N-phenylpropanehydrazonoyl chlorides have been utilized in numerous one-step heteroannulation reac...