RING Finger Protein 11 promotes melanoma metastasis via TGF- β signaling.

• Main Author: Xu, Ruiping.
• Other Authors: Feng Zhiwei
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/52707
• Institution: Nanyang Technological University

Malignant melanoma accounts for 75% of skin cancer death and the 5-year survival rate is less than 5%, due to the lacking of effective treatment for tumor metastasis. Preliminary study has identified RNF11 as a potential regulator of melanoma metastasis by using insertional mutagenesis. RING finger...