Fragment screening for stabilizers and binders to human DJ-1

• Main Author: Oh, Xu Xuan
• Other Authors: -
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2016
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology; DRNTU::Science::Biological sciences::Biophysics
• Online Access: http://hdl.handle.net/10356/68921
• Institution: Nanyang Technological University

Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease that is on the rise. Currently, treatments are only available to alleviate the span of symptoms but not to cure the morbidity. This project focuses on finding ligands to increase the stability of DJ1 where its anti-oxidant p...