Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells

• Main Authors: Chang, Kenneth T. E., Preiser, Peter R., Loh, Eva, Chen, Qingfeng, Amaladoss, Anburaj, Ye, Weijian, Wong, Lan Hiong, Loo, Hooi Linn, Liu, Min, Dummler, Sara, Kong, Fang, Tan, Shu Qi, Tan, Thiam Chye, Dao, Ming, Suresh, Subra, Chen, Jianzhu
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Cytology
• Online Access: https://hdl.handle.net/10356/79791; http://hdl.handle.net/10220/19421
• Institution: Nanyang Technological University

Immunodeficient mouse–human chimeras provide a powerful approach to study host-specific pathogens, such as Plasmodium falciparum that causes human malaria. Supplementation of immunodeficient mice with human RBCs supports infection by human Plasmodium parasites, but these mice lack the human immune s...