High-resolution RNA allelotyping along the inactive X chromosome: evidence of RNA polymerase III in regulating chromatin configuration

• Main Authors: Hong, Ru, Lin, Bingqing, Lu, Xinyi, Lai, Lan-Tian, Chen, Xin, Sanyal, Amartya, Ng, Huck-Hui, Zhang, Kun, Zhang, Li-Feng
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Epigenomics; Gene silencing
• Online Access: https://hdl.handle.net/10356/83042; http://hdl.handle.net/10220/42380
• Institution: Nanyang Technological University

We carried out padlock capture, a high-resolution RNA allelotyping method, to study X chromosome inactivation (XCI). We examined the gene reactivation pattern along the inactive X (Xi), after Xist (X-inactive specific transcript), a prototype long non-coding RNA essential for establishing X chromoso...