Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms

• Main Authors: Chua, Song Lin, Yam, Joey Kuok Hoong, Hao, Piliang, Adav, Sunil S., Salido, May Margarette, Liu, Yang, Givskov, Michael, Sze, Siu Kwan, Tolker-Nielsen, Tim, Yang, Liang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Biofilms; Bacterial Infection
• Online Access: https://hdl.handle.net/10356/83880; http://hdl.handle.net/10220/42860
• Institution: Nanyang Technological University

Drug resistance and tolerance greatly diminish the therapeutic potential of antibiotics against pathogens. Antibiotic tolerance by bacterial biofilms often leads to persistent infections, but its mechanisms are unclear. Here we use a proteomics approach, pulsed stable isotope labelling with amino ac...