In Vitro and In Vivo Efficacy of an LpxC Inhibitor, CHIR-090, Alone or Combined with Colistin against Pseudomonas aeruginosa Biofilm

• Main Authors: Tan, Jun Hou, Vidaillac, Celine, Yam, Joey Kuok Hoong, Chua, Song Lin, Givskov, Michael, Yang, Liang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: LpxC inhibitor; Pseudomonas aeruginosa
• Online Access: https://hdl.handle.net/10356/83882; http://hdl.handle.net/10220/42878
• Institution: Nanyang Technological University

With the rapid spread of antimicrobial resistance in Gram-negative pathogens, biofilm-associated infections are increasingly harder to treat and combination therapy with colistin has become one of the most efficient therapeutic strategies. Our study aimed to evaluate the potential for the synergy of...