Binding of anti-apoptotic Bcl-2 with different BH3 peptides : a molecular dynamics study
In this work, molecular dynamics simulation and free energy calculations are utilized to study how different BH3 peptides originating from Bax, Bim, Bik and Noxa interact with Bcl-2, one of the main members of anti-apoptotic proteins. The effects of peptide length, sequence and helical content on th...
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| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/87743 http://hdl.handle.net/10220/45473 |
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| Institution: | Nanyang Technological University |
| Language: | English |