The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

• Main Authors: Zhai, Weiwei, Choo, Su-Pin, Khor, Chiea Chuen, Lim, Tony Kiat-Hon, Zhang, Tong, Phang, Su-Ting, Tiang, Zenia, Guan, Peiyong, Ng, Ming-Hwee, Lim, Jia Qi, Yao, Fei, Li, Zheng, Ng, Poh Yong, Yan, Jie, Goh, Brian K., Chung, Alexander Yaw-Fui, Soon, Wendy Wei-Jia, Sung, Ken Wing-Kin, Foo, Roger Sik-Yin, Chow, Pierce Kah-Hoe
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Copy Number Variation; Cancer Genomics
• Online Access: https://hdl.handle.net/10356/89607; http://hdl.handle.net/10220/44986
• Institution: Nanyang Technological University

Hepatocellular carcinoma (HCC) has one of the poorest survival rates among cancers. Using multi-regional sampling of nine resected HCC with different aetiologies, here we construct phylogenetic relationships of these sectors, showing diverse levels of genetic sharing, spanning early to late diversif...