Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites

• Main Authors: Iyer, Jayasree K., Genesan, Saraswathy, Rajamanonmani, Ravikumar, Lescar, Julien, Bozdech, Zbynek, Preiser, Peter Rainer, Gao, Xiaohong, Yeo, Kim Pin, Aw, Sharon Siqi, Kuss, Claudia
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Immunology
• Online Access: https://hdl.handle.net/10356/93948; http://hdl.handle.net/10220/7060
• Institution: Nanyang Technological University

Invasion by the malaria merozoite depends on recognition of specific erythrocyte surface receptors by parasite ligands. Plasmodium falciparum uses multiple ligands, including at least two gene families, reticulocyte binding protein homologues (RBLs) and erythrocyte binding proteins/ligands (EBLs). T...