Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) expression by nanofiber-mediated siRNA gene silencing

• المؤلفون الرئيسيون: Rujitanaroj, Pim-On, Jao, Brian, Yang, Junghoon, Wang, Feng, Anderson, James M., Wang, Jun, Chew, Sing Yian
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Medicine::Biomedical engineering
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/99728; http://hdl.handle.net/10220/9960
• المؤسسة: Nanyang Technological University

The foreign body reaction often interferes with the long-term functionality and performance of implanted biomedical devices through fibrous capsule formation. While many implant modification techniques have been adopted in attempts to control fibrous encapsulation, the outcomes remained sub-optimal....