A Unifying Mechanism for Cancer Cell Death through Ion Channel Activation by HAMLET

• Main Authors: Storm P., Kjaer Klausen T., Trulsson M., Ho CS J., Dosnon M., Westergren T., Chao Y., Rydström A., Yang H., Pedersen S.F., Svanborg C.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: antineoplastic agent; calcium ion; human alpha lactalbumin made lethal to tumor cell; mitogen activated protein kinase p38; potassium ion; sodium ion; unclassified drug; antineoplastic activity; apoptosis; article; cell structure; cell viability; controlled study; enzyme activation; enzyme inhibition; enzyme phosphorylation; human; human cell; immunostimulation; ion transport; nucleotide sequence; signal transduction; tumor cell destruction; Biological Transport; Calcium; Cell Death; Cell Line, Tumor; Cluster Analysis; Gene Expression Profiling; Humans; Immunity, Innate; Intracellular Space; Ion Channels; Lactalbumin; Oleic Acids; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Potassium; Signal Transduction; Sodium
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161337
• Institution: National University of Singapore

10.1371/journal.pone.0058578