GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells

• Main Authors: Subhash, V.V, Tan, S.H, Tan, W.L, Yeo, M.S, Xie, C, Wong, F.Y, Kiat, Z.Y, Lim, R, Yong, W.P
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: BioMed Central Ltd. 2020
• Subjects: cisplatin; docetaxel; fluorouracil; short hairpin RNA; antineoplastic agent; GTSE1 protein, human; microtubule associated protein; adult; aged; apoptosis; Article; cancer adjuvant therapy; cancer cell; cancer prognosis; cancer resistance; cell assay; cell nucleus; cell proliferation; cell survival; cellular distribution; clinical article; clonogenic assay; colony formation; colorimetry; concentration response; controlled study; diagnostic test accuracy study; DNA determination; DNA methylation; down regulation; drug cytotoxicity; drug response; drug sensitivity; female; gastric cancer cell line; gene control; gene expression profiling; gene function; gene location; gene silencing; genetic correlation; genetic identification; genetic marker; GTSE1 gene; human; human cell; human tissue; male; predictive value; reverse transcription polymerase chain reaction; signal transduction; stomach cancer; tissue distribution; tumor suppressor gene; upregulation; Western blotting; drug effects; drug resistance; genetics; metabolism; middle aged; pathology; Stomach Neoplasms; tumor cell line; Adult; Aged; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cisplatin; DNA Methylation; Drug Resistance, Neoplasm; Female; Humans; Male; Microtubule-Associated Proteins; Middle Aged; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174282
• Institution: National University of Singapore

10.1186/s12885-015-1550-0