DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

• Main Authors: Wang, Y.-H, Hariharan, A, Bastianello, G, Toyama, Y, Shivashankar, G.V, Foiani, M, Sheetz, M.P
• Other Authors: MECHANOBIOLOGY INSTITUTE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: actin; ATR protein; cell nucleus receptor; checkpoint kinase 1; inositol polyphosphate; inositol polyphosphate multikinase; latrunculin A; messenger RNA; nuclear protein; nuclear receptor protein SF1; phosphatidylinositide; unclassified drug; wortmannin; ATM protein; ATR protein, human; CHEK1 protein, human; phosphatidylinositol; phosphotransferase; steroidogenic factor 1; chemical reaction; DNA; enzyme; enzyme activity; metabolism; nervous system disorder; protein; animal cell; Article; controlled study; DNA damage response; DNA repair; embryo; enzyme activation; enzyme phosphorylation; gene expression; lipid storage; mouse; nonhuman; phosphoinositide metabolism; pleckstrin homology domain; protein assembly; protein binding; protein depletion; protein expression; RNA splicing; signal transduction; animal; cell line; DNA damage; genetics; human; RNA interference; tumor cell line; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Line; Cell Line, Tumor; Checkpoint Kinase 1; DNA Damage; DNA Repair; Humans; Mice; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); RNA Interference; Signal Transduction; Steroidogenic Factor 1
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174372
• Institution: National University of Singapore

10.1038/s41467-017-01805-9