IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel

• Main Authors: Wee, Z.N, Yatim, S.M.J.M, Kohlbauer, V.K, Feng, M, Goh, J.Y, Yi, B, Lee, P.L, Zhang, S, Wang, P.P, Lim, E, Tam, W.L, Cai, Y, Ditzel, H.J, Hoon, D.S.B, Tan, E.Y, Yu, Q
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: apoptosis; cancer; gene expression; hormone; rabies; secretion; tumor; antineoplastic agent; interleukin 1 receptor associated kinase; IRAK1 protein, human; paclitaxel; animal; antagonists and inhibitors; Breast Neoplasms; cell proliferation; drug effects; drug resistance; enzymology; female; genetics; human; metabolism; metastasis; mouse; pathology; phosphorylation; SCID mouse; tumor cell line; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Female; Humans; Interleukin-1 Receptor-Associated Kinases; Mice; Mice, SCID; Neoplasm Metastasis; Paclitaxel; Phosphorylation
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180422
• Institution: National University of Singapore

10.1038/ncomms9746