Cytoglobosins H and I, new antiproliferative cytochalasans from deep-sea-derived fungus Chaetomium globosum

• Main Authors: Zhang, Z, Min, X, Huang, J, Zhong, Y, Wu, Y, Li, X, Deng, Y, Jiang, Z, Shao, Z, Zhang, L, He, F
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: 2020
• Subjects: antineoplastic agent; chaetoglobosin B; chaetoglobosin E; chaetoglobosin F; cisplatin; cytoglobosin B; cytoglobosin C; cytoglobosin H; cytoglobosin I; isochaetoglobosin D; unclassified drug; indole alkaloid; animal cell; antineoplastic activity; antiproliferative activity; apoptosis; Article; B16F10 cell line; cancer inhibition; Chaetomium globosum; controlled study; cytotoxicity; drug isolation; drug potency; drug structure; human; human cell; IC50; LNCaP cell line; male; MDA-MB-231 cell line; melanoma cell; mouse; nonhuman; animal; cell proliferation; Chaetomium; chemistry; drug effects; drug screening; fermentation; high performance liquid chromatography; isolation and purification; mass spectrometry; nuclear magnetic resonance spectroscopy; solid phase extraction; tumor cell line; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Fermentation; Humans; Indole Alkaloids; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Solid Phase Extraction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181321
• Institution: National University of Singapore

10.3390/md14120233