Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease

• Main Authors: CRYSTALL MARIE DAWN SWARBRICK, Vasiliki Zogali, Chan Wing Ki Kitti, Dimitrios Kiousis, GWEE CHIN PIAW, WANG SAI, Julien Lescar, Dahai Luo, Mark von Itzstein, Minos-Timotheos Matsoukas, George Panagiotakopoulos, Vasudevan, S.G., Gerasimos Rassias
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2022
• Subjects: Amidines; Amidoximes; Antiviral agents; Dengue and flaviviruses; Multimodal allosteric inhibitors; NS3 internal cleavage; Prodrugs; Structure-activity relationships; Viral protease NS2BNS3.
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/217876
• Institution: National University of Singapore

10.1016/j.ejmech.2021.113695