STRUCTURAL AND FUNCTIONAL STUDIES OF THE RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASE ?(PTP?)

by LIM KAH LEONG
Published 2019

The mood stabilizer lithium slows down synaptic vesicle cycling at glutamatergic synapses

by Tang, Willcyn, Cory, Bradley, Lim, Kah-Leong, Fivaz, Marc
Published 2023

Mitochondrial dysfunction and Parkinson’s disease — near-infrared photobiomodulation as a potential therapeutic strategy

by Foo, Aaron Song Chuan, Soong, Tuck Wah, Yeo, Tseng Tsai, Lim, Kah-Leong
Published 2021

Drosophila expressing human SOD1 successfully recapitulates mitochondrial phenotypic features of familial Amyotrophic Lateral Sclerosis

by Gallart-Palau, Xavier, Ng, Chee-Hoe, Ribera, Joan, Sze, Siu Kwan, Lim, Kah-Leong
Published 2016

Mitochondria targeting drugs for neurodegenerative diseases - design, mechanism and application

by Xu, Jiajia, Du, Wei, Zhao, Yunhe, Lim, Kah Leong, Lu, Li, Zhang, Chengwu, Li, Lin
Published 2023

From 2D to 3D: development of monolayer dopaminergic neuronal and midbrain organoid cultures for Parkinson's disease modeling and regenerative therapy

by Yeap, Yee Jie, Tng, Teddy J. W., Lee, Mok Jung, Goh, Micaela, Lim, Kah-Leong
Published 2023

Visualization of accessible cholesterol using a GRAM domain-based biosensor

by Koh, Dylan Hong Zheng, Naito, Tomoki, Na, Minyoung, Yeap, Yee Jie, Rozario, Pritisha, Zhong, Franklin, Lim, Kah-Leong, Saheki, Yasunori
Published 2024

Activation of autophagy ameliorates age-related neurogenesis decline and neurodysfunction in adult mice

by Yang, Na, Liu, Xueqin, Niu, Xiaojie, Wang, Xiaoqiang, Jiang, Rong, Yuan, Na, Wang, Jianrong, Zhang, Chengwu, Lim, Kah-Leong, Lu, Li
Published 2022

Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice

by Yang, Jing, Yang, Na, Zhao, Huifang, Qiao, Yan, Li, Yanqiu, Wang, Chunfang, Lim, Kah-Leong, Zhang, Chengwu, Yang, Wulin, Lu, Li
Published 2023

Conditional disruption of AMP kinase in dopaminergic neurons promotes Parkinson's disease-associated phenotypes in vivo

by Hang, Liting, Wang, Ziyin, Foo, Aaron S. C., Goh, Geraldine, Choong, Huey Ching, Thundyil, John, Xu, Shengli, Lam, Kong-Peng, Lim, Kah-Leong
Published 2022

Improved bioavailability of levodopa using floatable spray-coated microcapsules for the management of Parkinson’s disease

by Baek, Jong-Suep, Tee, Jie Kai, Pang, Yi Yun, Tan, Ern Yu, Lim, Kah Leong, Ho, Han Kiat, Loo, Joachim Say Chye
Published 2019

Prostaglandin A2 interacts with Nurr1 and ameliorates behavioral deficits in Parkinson's disease fly model

by Rajan, Sreekanth, Toh, Hui Ting, Ye, Hong, Wang, Ziyin, Basil, Adeline Henry, Parnaik, Tanvi, Yoo, Jun Yeob, Lim, Kah-Leong, Yoon, Ho Sup
Published 2022

Vascular bed molecular profiling by differential systemic decellularization in vivo

by Serra, Aida, Gallart-Palau, Xavier, Park, Jung Eun, Lim, Grace Gui Yin, Lim, Kah Leong, Ho, Hee Hwa, Tam, James Pingkwan, Sze, Siu Kwan
Published 2020

Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia

by Selvaraji, Sharmelee, Efthymios, Motakis, Foo, Roger Sik Yin, Fann, David Y, Lai, Mitchell Kim Peng, Chen, Christopher Li Hsian, Lim, Kah Leong, Arumugam, Thiruma
Published 2022

Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia

by Selvaraji, Sharmelee, Efthymios, Motakis, Foo, Roger Sik Yin, Fann, David Y., Lai, Mitchell Kim Peng, Chen, Christopher Li Hsian, Lim, Kah-Leong, Arumugam, Thiruma V.
Published 2022

Vitamin B12 ameliorates the pathological phenotypes of multiple Parkinson’s disease models by alleviating oxidative stress

by Wu, Yue, Zhao, Zhongting, Yang, Naidi, Xin, Chenqi, Li, Zheng, Xu, Jiajia, Ma, Bo, Lim, Kah-Leong, Li, Lin, Wu, Qiong, Yu, Changmin, Zhang, Chengwu
Published 2023

Customized strategies for high-yield purification of retinal pigment epithelial cells differentiated from different stem cell sources

by Regha, Kakkad, Bhargava, Mayuri, Al-Mubaarak, Abdurrahmaan, Chai, Chou, Parikh, Bhav Harshad, Liu, Zengping, Wong, Claudine See Wei, Hunziker, Walter, Lim, Kah Leong, Su, Xinyi
Published 2023

Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease

by Tang, Willcyn, Thundyil, John, Lim, Grace Gui Yin, Tng, Teddy J. W., Yeow, Sean Qing Zhang, Nair, Aditya, Chai, Chou, Yao, Tso-Pang, Lim, Kah-Leong
Published 2023

Convergence of parkin, PINK1, and α-synuclein on stress-induced mitochondrial morphological remodeling

by Norris, K.L., Hao, R., Chen, L.-F., Lai, C.-H., Kapur, M., Shaughnessy, P.J., Chou, D., Yan, J., Taylor, J.P., Engelender, S., West, A.E., Lim Kah Leong, Yao, T.-P.
Published 2016

MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration

by Ren, Mengda, Yang, Ying, Heng, Kelsey Hwee Yee, Ng, Lu Yi, Chong, Claris Yuin-Yi, Ng, Yan Ting, Gorur-Shandilya, Srinivas, Lee, Rachel Min Qi, Lim, Kah Leong, Zhang, Jing, Koh, Tong-Wey
Published 2023