Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines
As the only mammalian Argonaute protein capable of directly cleaving mRNAs in a small RNA-guided manner, Argonaute-2 (Ago2) is a keyplayer in RNA interference (RNAi) silencing via small interfering (si) or short hairpin (sh) RNAs. It is also a rate-limiting factor whose saturation by si/shRNAs limit...
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Main Authors: | Börner, Kathleen, Niopek, Dominik, Cotugno, Gabriella, Kaldenbach, Michaela, Pankert, Teresa, Willemsen, Joschka, Zhang, Xian, Schürmann, Nina, Streetz, Konrad, Kräusslich, Hans-Georg, Mockenhaupt, Stefan, Serva, Andrius, Grimm, Dirk, Hiet, Marie-Sophie, Wiedtke, Ellen, Binder, Marco, Castoldi, Mirco, Starkuviene, Vytaute, Erfle, Holger, Bartenschlager, Ralf, Boutros, Michael, Gilbert, Daniel F. |
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Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2014
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/101612 http://hdl.handle.net/10220/18735 |
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Institution: | Nanyang Technological University |
Language: | English |
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