Copper-catalyzed aerobic aliphatic C–H oxygenation with hydroperoxides

• Main Authors: Too, Pei Chui, Tnay, Ya Lin, Chiba, Shunsuke
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/102607; http://hdl.handle.net/10220/19181
• Institution: Nanyang Technological University

We report herein Cu-catalyzed aerobic oxygenation of aliphatic C–H bonds with hydroperoxides, which proceeds by 1,5-H radical shift of putative oxygen-centered radicals (O-radicals) derived from hydroperoxides followed by trapping of the resulting carbon-centered radicals with molecular oxygen.