Selective bi-directional amide bond cleavage of N-methylcysteinyl peptide

A selective bi-directional peptide bond cleavage mediated by N-methylcysteine (MeCys) in Xaa-MeCys-Yaa peptides (Xaa and Yaa, non-cysteine residues) leading to thioesters and thiolactones is described. Rate and product analyses showed that an Nα-amide bond cleavage occurred at the Xaa-MeCys bond by...

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Bibliographic Details
Main Authors: Qiu, Yibo, Hemu, Xinya, Liu, Ding Xiang, Tam, James P.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2014
Subjects:
Online Access:https://hdl.handle.net/10356/103981
http://hdl.handle.net/10220/20068
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Institution: Nanyang Technological University
Language: English

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