Selective bi-directional amide bond cleavage of N-methylcysteinyl peptide
A selective bi-directional peptide bond cleavage mediated by N-methylcysteine (MeCys) in Xaa-MeCys-Yaa peptides (Xaa and Yaa, non-cysteine residues) leading to thioesters and thiolactones is described. Rate and product analyses showed that an Nα-amide bond cleavage occurred at the Xaa-MeCys bond by...
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Main Authors: | Qiu, Yibo, Hemu, Xinya, Liu, Ding Xiang, Tam, James P. |
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Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2014
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/103981 http://hdl.handle.net/10220/20068 |
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Institution: | Nanyang Technological University |
Language: | English |
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