Carbene-catalyzed enantioselective addition of benzylic carbon to unsaturated acyl azolium for rapid synthesis of pyrrolo[3,2- c]quinolines
A carbene-catalyzed enantioselective addition of benzylic carbon to α,β-unsaturated acyl azolium intermediate generated via N-heterocyclic carbene catalysis is disclosed. This addition is followed by a stereoselective Mannich reaction and a chemo-selective lactam formation cascade to afford pyrrolo[...
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| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/138266 |
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| Institution: | Nanyang Technological University |
| Language: | English |