In vitro phosphodiesterase 10A (PDE10A) binding in whole hemisphere human brain using the PET radioligand [18F]MNI-659

• Main Authors: Svedberg, Marie M., Varnäs, Katarina, Varrone, Andrea, Mitsios, Nicholas, Mulder, Jan, Gulyás, Balázs, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Zaleska, Margaret M., Schmidt, Christopher J., Halldin, Christer, Mrzljak, Ladislav
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Autoradiography; Phosphodiesterase 10A
• Online Access: https://hdl.handle.net/10356/151071
• Institution: Nanyang Technological University

Highly specific and sensitive biomarkers for pathologies related to dysfunctions in the basal ganglia circuit are of great value to assess therapeutic efficacy not only clinically to establish an early diagnosis, but also in terms of monitoring the efficacy of therapeutic interventions and decelerat...